GenScript Tgfb1, Bovine; 1mg

GenScript TGF-B1 (transforming growth factor beta 1) is one of three closely related mammalian members of the large TGF-B1 superfamily that share a characteristic cystine knot structure. TGF-B1, -2 and -3 are highly pleiotropic cytokines that act as cellular switches to regulate processes such as immune function, proliferation and epithelial-mesenchymal transition. Each TGF-B isoform has some non-redundant function; for TGF-B1, mice with targeted deletion show defects in hematopoiesis and endothelial differentiation and died of overwhelming inflammation. TGF-B1 signaling begins with high-affinity binding to a type II ser/thr kinase receptor termed TGF-B RII. This receptor then phosphorylates and activates a second ser/thr kinase receptor, TGF-B RI (also called activin receptor‑like kinase (ALK)-5), or alternatively, ALK-1. This complex phosphorylates and activates Smad proteins that regulate transcription. - GSCRPT (Additional S&H or Hazmat Fees May Apply)