AG Scientific Celastrol, 5 MG

Celastrol (also known as Tripterin) is a cell-permeable proteasome inhibitor. Celastrol acts as an antioxidant, anti-inflammatory and immunosuppressive agent. It suppresses LPS-induced cytokine release in macrophages and monocytes (IC= 40 nM for IL-1 and IL-1, 80 nM for IL-6, 110 nM for prostaglandin E2 and 210 nM for IL-8 and TNF).

Celastrol suppresses nitric oxide production (IC= 230 nM) and LPS-induced NF-B activation (IC= 270 nM). It inhibits chymotrypsin-like activity of 20S proteasome (IC= 2.5 M) and lipid peroxidation induced by ADP and Fe in rat liver mitochondria (IC= 7 M).

Isolated fromTripterygium wilfordii.