Cell Signaling Arp2 Antibody

Name: Cell Signaling Arp2 Antibody
SKU: CSIG-3128T
Price: 132.31 USD

List Price $132.31 Your Price $132.31

Cell Signaling Arp2 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-3128T

MFG.PART: 3128T

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	20 µl
Reactivity	H M R Hm Mk Dm
Sensitivity	Endogenous
Molecular Weight (kDa)	44
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	ARP2 Antibody detects endogenous levels of total ARP2 protein.
Species Reactivity	Human, Mouse, Rat, Hamster, Monkey, D. melanogaster
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the sequence of human ARP2.
Background	Actin nucleation, the formation of new actin filaments from existing filaments, affects actin filament structure during cell motility, division, and intracellular trafficking. An important actin nucleation protein complex is the highly conserved ARP2/3 complex, consisting of ARP2, ARP3, and ARPC1-5. The ARP2/3 complex promotes branching of an existing actin filament and formation of a daughter filament following activation by nucleation-promoting factors, such as WASP/WAVE or cortactin (1). The formation of podosomes, small cellular projections that degrade the extracellular matrix, is enhanced by ARP2/3 complex action. ARP2/3 competes with caldesmon, an actin binding protein shown to negatively affect podosome formation (2). Along with N-WASP, the ARP2/3 complex regulates nuclear actin filament nucleation and controls actin polymerization during transcription (3).

Specifications