Cell Signaling Keratin 20 (D9z1z) Xp ® Rabbit mAb (Bsa And Azide Free)

Name: Cell Signaling Keratin 20 (D9z1z) Xp ® Rabbit mAb (Bsa And Azide Free)
SKU: CSIG-94369SF
Price: 851.43 USD

List Price $851.43 Your Price $851.43

Cell Signaling Keratin 20 (D9z1z) Xp ® Rabbit mAb (Bsa And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-94369SF

MFG.PART: 94369SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	48
Source/Isotype	Rabbit
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free.For standard formulation of this product see product #13063
Specificity/Sensitivity	Keratin 20 (D9Z1Z) XP® Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of total keratin 20 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human keratin 20 protein.
Background	Keratins (cytokeratins) are intermediate filament proteins that are mainly expressed in epithelial cells. Keratin heterodimers composed of an acidic keratin (or type I keratin, keratins 9 to 23) and a basic keratin (or type II keratin, keratins 1 to 8) assemble to form filaments (1,2). Keratin isoforms demonstrate tissue- and differentiation-specific profiles that make them useful as research biomarkers (1). Research studies have shown that mutations in keratin genes are associated with skin disorders, liver and pancreatic diseases, and inflammatory intestinal diseases (3-6).Keratin 20 is primarily expressed in gastric and intestinal epithelium, urothelium, and Merkel cells (7). Research studies have shown that keratin 20 is an important marker of colon, liver, pancreatic, Merkel cell, and gastric cancer (8).

Specifications