Cell Signaling Acetyl-Coa Carboxylase (C83b10) Rabbit mAb (Bsa And Azide Free)

Name: Cell Signaling Acetyl-Coa Carboxylase (C83b10) Rabbit mAb (Bsa And Azide Free)
SKU: CSIG-52923SF
Price: 851.43 USD

List Price $851.43 Your Price $851.43

Cell Signaling Acetyl-Coa Carboxylase (C83b10) Rabbit mAb (Bsa And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-52923SF

MFG.PART: 52923SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µg
Reactivity	H M R Hm
Sensitivity	Endogenous
Molecular Weight (kDa)	280
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free.For standard formulation of this product see product #3676
Specificity/Sensitivity	Acetyl-CoA Carboxylase (C83B10) Rabbit mAb (BSA and Azide Free) detects endogenous levels of all isoforms of acetyl-CoA carboxylase protein.
Species Reactivity	Human, Mouse, Rat, Hamster
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser523 of human acetyl-CoA carboxylase α1.
Background	Acetyl-CoA carboxylase (ACC) catalyzes the carboxylation of acetyl-CoA to malonyl-CoA (1). It is the key enzyme in the biosynthesis and oxidation of fatty acids (1). In rodents, the 265 kDa ACC1 (ACCα) form is primarily expressed in lipogenic tissues, while 280 kDa ACC2 (ACCβ) is the main isoform in oxidative tissues (1,2). However, in humans, ACC2 is the predominant isoform in both lipogenic and oxidative tissues (1,2). Phosphorylation by AMPK at Ser79 or by PKA at Ser1200 inhibits the enzymatic activity of ACC (3). ACC is a potential target of anti-obesity drugs (4,5).

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