Cell Signaling Glul (D2o3f) Rabbit mAb (Ihc Formulated)

Name: Cell Signaling Glul (D2o3f) Rabbit mAb (Ihc Formulated)
SKU: CSIG-27857S
Price: 342.39 USD

List Price $342.39 Your Price $342.39

Cell Signaling Glul (D2o3f) Rabbit mAb (Ihc Formulated) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-27857S

MFG.PART: 27857S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M R
Sensitivity	Endogenous
Source/Isotype	Rabbit IgG
Application/Dilution	{Immunohistochemistry (Paraffin): 1:200}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	GLUL (D2O3F) Rabbit mAb (IHC Formulated) recognizes endogenous levels of total GLUL protein.
Species Reactivity	Human, Mouse, Rat
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala297 of human GLUL protein.
Background	Glutamate-ammonia ligase (GLUL), also known as glutamine synthetase (GS), catalyzes the de novo synthesis of glutamine from glutamate and ammonia. GLUL is ubiquitously expressed with particularly high expression in the muscle, liver, and brain (1). GLUL expression is elevated in various cancers. Its expression is upregulated by oncogenic c-Myc (2). High expression of GLUL in breast cancer patients is associated with larger tumor size and high level of HER2 expression. It is a predictor of poor survival in patients with glioma and liver cancers (3-6).

Specifications