Cell Signaling Tie1 (D2k2t) Rabbit mAb

Name: Cell Signaling Tie1 (D2k2t) Rabbit mAb
SKU: CSIG-23111S
Price: 342.39 USD

List Price $342.39 Your Price $342.39

Cell Signaling Tie1 (D2k2t) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-23111S

MFG.PART: 23111S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	135, 140
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:100}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	TIE1 (D2K2T) Rabbit mAb recognizes endogenous levels of total TIE1 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human TIE1 protein.
Background	TIE1 belongs to the Tie family of receptor tyrosine kinases. TIE1 is structurally similar to its homolog TIE2, but differs from the latter in that it does not have a known ligand and is thus considered an orphan receptor (1). A key function of TIE1 is to modulate TIE2 signaling, via heterodimerization with TIE2 at the cell surface (2). The effects of TIE1-TIE2 interaction are context-dependent; heterodimerization can either promote or inhibit downstream TIE2 signaling depending on localized TIE2 levels (3-6). Research studies have shown TIE1 to be implicated in angiogenesis, vascular maturation, tissue remodeling, and inflammation. Increased expression of TIE1 has also been associated with cancer stemness and atherosclerosis formation (7, 8).

Specifications