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Cell Signaling Liprin Beta1 Antibody
List Price
$309.06
Your Price
$309.06
Cell Signaling Liprin Beta1 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)
NETA PART:
CSIG-18409S
MFG.PART:
18409S
UNSPSC:
12352203
Manufacturer:
Cell Signaling
| Size | 100 µl |
| Reactivity | H M R Mk |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 140 |
| Source/Isotype | Rabbit |
| Application/Dilution | {Western Blotting: 1:1000} |
| Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | Liprin β1 Antibody recognizes endogenous levels of total Liprin β1 protein. |
| Species Reactivity | Human, Mouse, Rat, Monkey |
| Source/Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser510 of human Liprin β1 protein. Antibodies are purified by protein A and peptide affinity chromatography. |
| Background | Liprins are a family of proteins known to function as LAR (leukocyte common antigen-related) transmembrane protein tyrosine phosphatase-interacting proteins (1). This interaction has been studied in connection to both axon guidance and mammary gland development (1,2). Liprin β1, a member of this family, is a widely expressed, multivalent cytosolic protein. Liprin β1 has been found to homodimerize at the N terminus and to heterodimerize with Liprin α1 and the metastasis-associated protein S100A4 at the C terminus (1,2). The interaction with S100A4 is believed to both inhibit its phosphorylation and to modulate complex formation with Liprin α1, resulting in a change in LAR cell adhesion properties, thus promoting cell motility and tumor metastasis (2). Liprin β1 has also been shown to have higher expression levels and to associate with KANK proteins in melanoma and to be a potential regulator of lymphatic vessel integrity (3,4). |
| SKU | CSIG-18409S |
|---|---|
| Featured | No |
| Supplier Part Number | 18409S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer Name | Cell Signaling |
| MSDS URL | Click here |
| Temperature | -20C |
| CountryOfOrigin | United States |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| ACT Ecolabel | No |