Sigma-Aldrich Albumin, Human Serum, Fraction V, High Purity

Human serum albumin (HSA) is an unglycosylated, soluble, and globular monomeric protein.[1] It is abundantly found in the plasma,[2] with a multidomain comprising three homologous domains, called I, II, and III.[2][3] Three of these domains have subdomains A and B with common structural motifs. The HSA gene is localized on the human chromosome 4q13.3.[3]

Albumin, human serum, fraction V, high purity has been used to determine the binding affinity of nanobody α human serum albumin (HSA) to HSA and injected to detect the signals of tandem binding of human interleukin (IL-21R), IL-21-αHSA, and HSA.[4] It has also been used to study the effects of fetuin-A phosphorylation on calciprotein particles (CPP) uptake.[5]

Human serum albumin (HSA) plays a major role as a carrier protein for fatty acids, thyroid hormones, and steroids.[1] It is involved in stabilizing extracellular fluid volume.[1] HSA is used to treat hemodialysis, acute liver failure, chronic liver disease.[2] It serves as an excipient for vaccines and therapeutic protein drugs.[1] HSA is implicated in biological applications, including ligand trapping, nano delivery of drugs, and fusion proteins.[2][1]

Toxicity: Standard Handling (A)

Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Alternatively, this product may be stored in the refrigerator (4°C) prior to reconstitution. Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.