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Millipore This Anti-Hu Gbp-1/Gbp-1 Antibody, Clone 6c5.1 Is Validated For Use In Western Blotting & Ihc (Paraffin) For The Detection Of Hu Gbp-1/Gbp-1. - Mill (Additional S&H or Hazmat Fees May Apply)
mgbp-2/hGBP-1, or also known as Interferon-induced guanylate-binding protein 1, GTP-binding protein 1 (GBP-1/HuGBP-1), or Guanine nucleotide-binding protein 1, and encoded by the gene GBP1, is another enzyme important in innate defense. Among its functions, this enzyme hydrolyzes GTP to GMP and appears to promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, thus providing broad host protection against different pathogen classes. mgbp-2/hGBP-1 is localized to the cytoplasm but is also secreted in endothelial cells and localizes to the cytoplasmic side of the Golgi apparatus in expressing most cells. Interestingly, mgbp-2/hGBP-1is secreted by the endothelial cells in the CNS upon bacterial challenge even when not induced by gamma interferon. The enzyme is also induced by TNF-alpha and IL-1beta expression by immune cells and is considered a proinflammatory response factor.
Product Information
Format
Purified
Presentation
Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
This Anti-Hu GBP-1/GBP-1 Antibody, clone 6C5.1 is validated for use in western blotting & IHC (Paraffin) for the detection of Hu GBP-1/GBP-1.
Key Applications
Western Blotting
Immunohistochemistry (Paraffin)
Application Notes
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected hu GBP-1/GBP-1 in human spleen tissues and rat brain tissue.
Biological Information
Immunogen
GST-tagged recombinant protein corresponding to hu GBP-1/GBP-1.
Clone
6C5.1
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Mouse
Isotype
IgG2aκ
Species Reactivity
Human
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NP_002044
Gene Symbol
GBP1
Purification Method
Protein G Purified
UniProt Number
P32455
Molecular Weight
~68 kDa observed
Product Usage Statements
Quality Assurance
Evaluated by Western Blotting in human spleen tissue lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected hu GBP-1/GBP-1 in 400 µg of human spleen tissue lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
