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Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H | WB | M | Purified | Monoclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | MABT107 |
| Description | Anti-Src-like-adapter Antibody/SLAP1, clone 1D9.1 |
| Alternate Names |
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| Background Information | Src-like-adapter/SLAP1 protein, also known as SLAP, and encoded by the gene SLA/SLAP/SLAP1, is an adapter protein which negatively regulates T cell receptor signaling by inhibiting T cell antigen induced proliferation and works to control the positive selection and mitosis of T cells. SLAP1 also acts to connect signaling proteins such as ZAP70 with the T cell specific CBL ubiquitin ligase that plays a central role in degrading signaling proteins, and a critical role in limiting or initiating the T-cell specific- antigen-specific immunotolerance limits in T cells activation. Src-like-adapter/SLAP1 is localized to the cytoplasm and endosomes within cells. Src-like-adapter/SLAP1 is expressed in lung and fetal brain, and weakly expressed in heart, adult brain, placenta, liver, skeletal muscle, kidney and pancreas. Recent research suggest that SLAP1 may also play a role in different cancers and in modulation of receptor tyrosine kinase signaling in cancers apart from its conventional role in regulation of T cell receptor stability. |
| Product Information | |
|---|---|
| Format | Purified |
| Presentation | Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide. |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | This Anti-Src-like-adapter Antibody/SLAP1, clone 1D9.1 is validated for use in western blotting for the detection of Src-like-adapter/SLAP1. |
| Key Applications |
|
| Biological Information | |
|---|---|
| Immunogen | Linear peptide corresponding to human Src-like-adapter/SLAP1. |
| Clone | 1D9.1 |
| Concentration | Please refer to the Certificate of Analysis for the lot-specific concentration. |
| Host | Mouse |
| Isotype | IgMκ |
| Species Reactivity |
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| Antibody Type | Monoclonal Antibody |
| Entrez Gene Number |
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| Gene Symbol |
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| Purification Method | Purified by Ion-Exchange Chromatography |
| UniProt Number |
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| Molecular Weight | ~38 kDa observed. The calculated molecular weight of this protein is 32 kDa; however, it may be observed at higher molecular weights due to known Post-translational modification sites. |
| Product Usage Statements | |
|---|---|
| Quality Assurance | Evaluated by Western Blotting in Human Lung tissue lysate. Western Blotting Analysis: A 1:5,000 dilution of this antibody detected Src-like-adapter/SLAP1 in 400 µg of human lung tissue lysate. |
| Usage Statement |
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| Storage and Shipping Information | |
|---|---|
| Storage Conditions | Stable for 1 year at 2-8°C from date of receipt. |
| Packaging Information | |
|---|---|
| Material Size | 100 µL |