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Millipore Anti-Ints1, Clone 4.47 Antibody, Cat. No. Mabs1984, Is A Highly Specific Mouse Monoclonal Antibody, That Targets Ints1 And Has Been Tested In Western Blotting. - Mill (Additional S&H or Hazmat Fees May Apply)
Integrator complex subunit 1 (UniProt Q8N201; also known as Int1) is encoded by the INTS1 (also known as KIAA1440, UNQ1821/PRO3434) gene (Gene ID 26173) in human. INTS1 is a large protein that is a component of the integrator complex that is involved in small nuclear RNAs U1 and U2 transcription and their 3-box-dependent processing. During transcriptional regulation and in RNA processing, it directly binds to the C-terminal domain of the RNA polymerase II largest subunit. It has been reported that INTS1 is also involved in different cell support processes, such as the formation of a scaffold for the assembly of integrator complex. Developing INTS1 (-/-) mouse embryos show growth arrest at the early blastocyst stage and exhibit activated caspase-3 and caspase-7 that induce apoptosis within the inner cell mass of blastocyst.
Ref.: Baillat, D et al. (2005). Cell 123, 265-276. Hata T., and Nakayama, M (2007), Biochim. Biophys. Acta 1773, 1039-1051.
Product Information
Format
Purified
Presentation
Purified mouse IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
Anti-INTS1, clone 4.47 Antibody, Cat. No. MABS1984, is a highly specific mouse monoclonal antibody, that targets INTS1 and has been tested in Western Blotting.
Key Applications
Western Blotting
Biological Information
Immunogen
GST-tagged recombinant human INTS1 internal fragment.
Clone
4.47
Concentration
Please refer to lot specific datasheet.
Host
Mouse
Specificity
Clone 4.47 targets an epitope in the central region of human INTS1 protein.
Isotype
IgG1κ
Species Reactivity
Human
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NP_001073922
Gene Symbol
INTS1
KIAA1440
UNQ1821/PRO3434
Purification Method
Protein G purified.
UniProt Number
Q8N201
Molecular Weight
~240 kDa observed. 244.3 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Product Usage Statements
Quality Assurance
Evaluated by Western Blotting in HeLa cell lysate.
Western Blotting Analysis: 2 µg/mL of this antibody detected in 50 µg of HeLa cell lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
