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Millipore This Anti-Ntr1 Antibody, Clone 8f11.1 Is Validated For Use In Western Blotting, Immunohistochemistry (Paraffin) For The Detection Of Ntr1 . - Mill (Additional S&H or Hazmat Fees May Apply)
Neurotensin receptor type 1 (UniProt P30989; also known as High-affinity levocabastine-insensitive neurotensin receptor, NT-R-1, NTR1, NTRH) is encoded by the NTSR1 (also known as NTRR) gene (Gene ID 4923) in human. Neurotensin (NT) is a tridecapeptide that acts as a neuromodulator in the CNS. It also behaves as a hormone in the gastrointestinal tract. Four different NTSRs have been reported. NTSR1 and NTSR2 are seven-transmembrane G-protein-coupled receptors (GPCRs), while NTSR3 and NTSR4 are members of the sortilin protein family with a single-transmembrane spanning domain. NTSR1 is a high affinity NT receptor and plays an important role in cancer cell proliferation, survival, mobility, and invasion. NT has also been implicated in the pathophysiology of several CNS disorders, such as schizophrenia, drug abuse, eating disorders, and Parkinson’s disease.
Product Information
Format
Purified
Presentation
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
This Anti-NTR1 Antibody, clone 8F11.1 is validated for use in Western Blotting, Immunohistochemistry (Paraffin) for the detection of NTR1 .
Key Applications
Western Blotting
Immunohistochemistry (Paraffin)
Application Notes
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected NTR1 in human thalamus and human frontal cortex tissue.
Biological Information
Immunogen
KLH-conjugated linear peptide corresponding to human NTR1 near the C-terminus.
Epitope
Near C-terminus
Clone
8F11.1
Concentration
Please refer to lot specific datasheet.
Host
Mouse
Isotype
IgG1κ
Species Reactivity
Human
Mouse
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NP_002522
Gene Symbol
NTSR1
NTRR
Purification Method
Protein G Purified
UniProt Number
P30989
Molecular Weight
~49 kDa observed. Uncharacterized band(s) may appear in some lysates.
Product Usage Statements
Quality Assurance
Evaluated by Western Blotting in mouse hypothalamus tissue lysate.
Western Blotting Analysis: 2.5 µg/mL of this antibody detected NTR1 in 10 µg of mouse hypothalamus tissue lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
