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Millipore Anti-Vitamin D3 Receptor Antibody, Clone 6f3.1, Cat. No. Mabn1601, Is A Highly Specific Mouse Monoclonal Antibody That Targets Vitamin D3 Receptor And Has Been Tested In Western Blotting. - Mill (Additional S&H or Hazmat Fees May Apply)
Vitamin D3 receptor (UniProt P11473; also known as 1,25-dihydroxyvitamin D3 receptor, Nuclear receptor subfamily 1 group I member 1, VDR) is encoded by the VDR (also known as NR1I1) gene (Gene ID 7421) in human. VDR is a member of the superfamily of nuclear receptors for steroid hormones and acts as a ligand-inducible transcription factor that targets vitamin D responsive elements. Upon ligand binding, VDR complexes with the retinoid-X receptor (RXR), the heterodimer then targets hormone-response elements, resulting in transcription or transrepression of specific genes. Ligand binding also induces a conformational change at the C-terminal ligand-binding domain (LBD; a.a. 192-427), resulting in recruitment of the p160/SRC family coactivators whose acetylase activity plays an important role in transcription modulations via chromatin remodeling. VDR gene mutations are associated with type II vitamin D-resistant rickets and alopecia (hair loss).
Product Information
Format
Purified
Presentation
Purified mouse IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
Anti-Vitamin D3 Receptor Antibody, clone 6F3.1, Cat. No. MABN1601, is a highly specific mouse monoclonal antibody that targets Vitamin D3 receptor and has been tested in Western Blotting.
Key Applications
Western Blotting
Biological Information
Immunogen
GST-tagged recombinant fragment corresponding to the N-terninal of human vitamin D3 receptor.
Clone
6F3.1
Concentration
Please refer to lot specific datasheet.
Host
Mouse
Specificity
Clone 6F3.1 targets an epitope present at the N-terminal half of both spliced isoforms of human vitamin D3 receptor reported by UniProt (P11473).
Isotype
IgG1κ
Species Reactivity
Human
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NP_000367
Gene Symbol
VDR
NR1I1
Purification Method
Protein G purified.
UniProt Number
P11473
Molecular Weight
~50 kDa observed. 48.29/53.88 kDa (isoform 1/2) calculated. Uncharacterized bands may be observed in some lysate(s).
Product Usage Statements
Quality Assurance
Evaluated by Western Blotting in T47D cell lysate.
Western Blotting Analysis: A 1:1,000 dilution of this antibody detected vitamin D3 receptor in 10 µg of T47D human breast cancer cell lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
