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Pituitary homeobox 3 (UniProt O75364; also known as Homeobox protein PITX3, Paired-like homeodomain transcription factor 3) is encoded by the PITX3 (also known as ASMD, CTPP4, CTRCT11, PTX3) gene (Gene ID 5309) in human. PITX3 is a bicoid-related homeodomain transcription factor critical for the development of the ocular lens, mesencephalic dopaminergic neurons and skeletal muscle. PITX3 exerts its developmental impact on dopaminergic neurons by directly regulating the expression of a cascade of downstream genes, including TH, VMAT2, DAT, BDNF, and GDNF. PITX3 and the related PITX2 are both key regulators of intracellular redox state and play an important role in preventing DNA damage during fetal myogenesis. Human PITX3 gene mutations are linked to cataracts and anterior segment abnormalities and PITX3 polymorphisms are associated with Parkinsons disease. In aphakia (ak) mice, deletions in the Pitx3 promoter region cause abnormal lens development.
Product Information
Format
Purified
Presentation
Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
Anti-PITX3 Antibody, clone 12G4.1 is an antibody against PITX3 for use in Western Blotting.
Key Applications
Western Blotting
Biological Information
Immunogen
KLH-conjugated linear peptide corresponding to a sequence within the N-terminal region of human PITX3.
Epitope
N-terminal region.
Clone
12G4.1
Concentration
Please refer to lot specific datasheet.
Host
Mouse
Isotype
IgG2aκ
Species Reactivity
Human
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NP_005020
Gene Symbol
PITX3
PTX3
ASMD
CTPP4
CTRCT11
Purification Method
Protein G Purified
UniProt Number
O75364
Molecular Weight
~32 kDa observed. Uncharacterized band(s) may appear in some lysates.
Product Usage Statements
Quality Assurance
Evaluated by Western Blotting in human retinoblastoma Y79 cell lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected PITX3 in 10 µg of human retinoblastoma Y79 cell lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
