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Millipore Anti-Fbpase 1, Clone 13a8.1 | Mabc543 Is An Antibody Against Fbpase 1 For Use In Western Blotting, Immunohistochemistry (Paraffin). - Mill (Additional S&H or Hazmat Fees May Apply)
Fructose-1, 6-bisphosphatase 1 (FBPase 1), also known as D-fructose-1, 6-bisphosphate 1-phosphohydrolase 1, and encoded by the gene name FBP1 and FBP, belongs to the FBPase class 1 family. FBPase 1 is a gluconeogenesis regulatory enzyme that catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations; thus, acting as a rate-limiting enzyme in gluconeogenesis. FBPase 1 has been demonstrated to play a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. FBPase 1 may be involved in modulating glycerol gluconeogenesis in liver. FBPase 1 has been studied as an important regulator of appetite and adiposity. Increased expression of FBPase 1 in liver, after nutrient excess, increases circulating satiety hormones and reduces appetite-stimulating neuropeptides. Therefore, FBPase 1 may be an important target that provides a feedback mechanism to limit weight gain. FBPase 1 is expressed mainly in pancreatic islets.
Product Information
Format
Purified
Presentation
Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
Anti-FBPase 1, clone 13A8.1 | MABC543 is an antibody against FBPase 1 for use in Western Blotting, Immunohistochemistry (Paraffin).
Key Applications
Western Blotting
Immunohistochemistry (Paraffin)
Application Notes
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected FBPase 1 in human pancreas tissue.
Biological Information
Immunogen
KLH-conjugated linear peptide corresponding to human FBPase 1.
Clone
13A8.1
Concentration
Please refer to lot specific datasheet.
Host
Mouse
Isotype
IgMκ
Species Reactivity
Human
Mouse
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NP_000498
Gene Symbol
FBP1
FBP
UniProt Number
P09467
Molecular Weight
~36 kDa observed. Uncharacterized band(s) may appear in some lysates.
Product Usage Statements
Quality Assurance
Evaluated by Western Blotting in mouse stomach tissue lysate.
Western Blotting Analysis: A 1:1,000 dilution of this antibody detected FBPase 1 in 10 µg of mouse stomach tissue lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
