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Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| M, R | FC, ICC, IHC, WB | M | Purified | Monoclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | MAB5680 |
| Brand Family | Chemicon® |
| Trade Name |
|
| Description | Anti-Myelin Oligodendrocyte Glycoprotein (MOG) Antibody |
| Alternate Names |
|
| Background Information | Myelin oligodendrocyte glycoprotein (MOG) is a key CNS-specific autoantigen for primary demyelination in multiple sclerosis. Although the disease-inducing role of MOG has been established, its precise function in the CNS remains obscure. MOG is a type I integral membrane protein possessing a single extracellular Ig variable domain (Ig-V) (3, 13, 14). The amino acid sequence of MOG is highly conserved among animal species (>90%), indicative of an important biological function. MOG is specifically expressed in the CNS on the outermost lamellae of the myelin sheath as well as the cell body and processes of oligodendrocytes. The developmentally late expression of MOG correlates with the later stages of myelinogenesis, suggesting that MOG has a role in the completion, compaction, and/or maintenance of myelin, further suggesting that MOG has an adhesive function within the CNS . Consistent with MOGs possible adhesive role in the CNS, a homodimeric form of MOG has not only been observed after isolation from the CNS but has additionally been observed in situ. |
| Product Information | |
|---|---|
| Format | Purified |
| Control |
|
| Presentation | Purified in 0.1 M Tris-Glycine, 0.15 M NaCl, pH 7.4 and 0.05% Sodium Azide |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | Anti-Myelin Oligodendrocyte Glycoprotein (MOG) Antibody is an antibody against Myelin Oligodendrocyte Glycoprotein (MOG) for use in FC, IC, IH & WB. |
| Key Applications |
|
| Biological Information | |
|---|---|
| Immunogen | Rat cerebellar glycoproteins |
| Epitope | The antibody binds to a discontinuous epitope present on the extracellular immunoglobulin V-like domain of MOG. |
| Clone | 8-18C5 |
| Concentration | Please refer to the Certificate of Analysis for the lot-specific concentration. |
| Host | Mouse |
| Specificity | Membane associated region of MOG [Myelin oligodendrocyte glycoprotein]. |
| Isotype | IgG1 |
| Species Reactivity |
|
| Species Reactivity Note | May cross react with human and bovine based on sequence similarity. |
| Antibody Type | Monoclonal Antibody |
| Entrez Gene Number |
|
| Purification Method | Purified immunoglobulin |
| UniProt Number |
|
| UniProt Summary | FUNCTION: Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. SUBUNIT: May form homodimers. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes. DEVELOPMENTAL STAGE: A peak of expression has been observed between postnatal days 15 and 25, coinciding with the period of active myelination. SIMILARITY: Belongs to the immunoglobulin superfamily. BTN/MOG family. SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) domain. CAUTION: Do not confuse myelin-oligodendrocyte glycoprotein (MOG) with oligodendrocyte-myelin glycoprotein (OMG). |
| Molecular Weight | 28 kDa |
| Product Usage Statements | |
|---|---|
| Quality Assurance | Routinely evaluated by immunoblot. |
| Usage Statement |
|
| Storage and Shipping Information | |
|---|---|
| Storage Conditions | Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt. |
| Packaging Information | |
|---|---|
| Material Size | 100 µg |