Special Offers
100% Performance Guaranteed
Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H, Mk, R, Rb | FC, IP, ICC, IHC | M | Purified | Monoclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | MAB2076Z |
| Brand Family | Chemicon® |
| Trade Name |
|
| Description | Anti-Integrin β6 Antibody, clone CSβ6, azide free |
| Alternate Names |
|
| Product Information | |
|---|---|
| Format | Purified |
| Presentation | Sterile-filtered liquid at 1 mg/mL in PBS, containing no preservatives. |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | Anti-Integrin β6 Antibody, clone CSβ6, azide free detects level of Integrin β6 & has been published & validated for use in FC, IP, IC, IH. |
| Key Applications |
|
| Application Notes | Immunohistochemistry (acetone fixation): Effective for Rabbit, rat, monkey, and human. Not effective for mouse tissue. Immunocytochemistry: Effective for F6, HT-29, H441 cell lines (others not tested). Flow cytometry: Effective for all species tested, including rabbit, rat, monkey, human, and mouse. Immunoprecipitation Optimal working dilutions must be determined by end user. |
| Biological Information | |
|---|---|
| Immunogen | beta 6 knockout mice have been immunized with recombinant secreted human alpaVbeta6. |
| Clone | CSbeta6 |
| Concentration | Please refer to the Certificate of Analysis for the lot-specific concentration. |
| Host | Mouse |
| Specificity | Monoclonal antibody MAB2076Z, raised by immunizing beta6 knockout mice with recombinant secreted human alphavbeta6, is useful for flow cytometry and immunoprecipitation in all species tested, including mouse. It also works well for immunohistochemistry of acetone-fixed tissues in several species, including rat, rabbit, monkey, and human. The antibody does not work well for immunohistochemistry of mouse tissue. This antibody does not recognize the aV subunit and does not react with alphaV integrins other than alphavbeta6. Because the antibody is not effective in western blot, it is unknown whether the epitope recognized by the antibody localizes to the alphavbeta6 heterodimer or to the beta6 subunit only. |
| Isotype | IgG1 |
| Species Reactivity |
|
| Antibody Type | Monoclonal Antibody |
| Entrez Gene Number |
|
| Gene Symbol |
|
| Non-Reactive Species |
|
| UniProt Number |
|
| UniProt Summary | FUNCTION: SwissProt: P18564 # Integrin alpha-V/beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. SIZE: 788 amino acids; 85936 Da SUBUNIT: Heterodimer of an alpha and a beta subunit. Beta-6 associates with alpha-V. Interacts with FLNB. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. SIMILARITY: SwissProt: P18564 ## Belongs to the integrin beta chain family. & Contains 1 VWFA domain. |
| Product Usage Statements | |
|---|---|
| Usage Statement |
|
| Storage and Shipping Information | |
|---|---|
| Storage Conditions | Maintain at 2-8°C. |
| Packaging Information | |
|---|---|
| Material Size | 100 µg |