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Millipore Anti-Kif5 Antibody Is An Antibody Against Kif5 For Use In Western Blotting, Icc & Immunofluorescence. - Mill (Additional S&H or Hazmat Fees May Apply)
Kinesin heavy chain isoform 5A, also known as Kinesin heavy chain neuron-specific 1 or Neuronal kinesin heavy chain (NKHC), and encoded by the gene name KIF5A or NKHC1, are members of the kinesin superfamily of proteins (KIFs). These proteins are microtubuledependent motors that slide along microtubules and transport cellular organelles and mRNA to different parts of the cell. In neurons, KIF5 performs this role in an anterograde fashion from the neuronal cell body to axonal or dendritic terminals. KIF5 was initially differentiated from the ubiquitously expressed kinesin as being highly enriched in subsets of neurons and selectively concentrated in the cell body. KIF5 has at least three known isoforms; KIF5A (117 kDa), KIF5B (39 kDa), and KIF5C (39 kDa). Mutations in one of the isoforms of KIF5 (KIF5A) is thought to be involved in hereditary spastic paraplegias
Product Information
Format
Affinity Purified
Presentation
Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Quality Level
MQ100
Applications
Application
Anti-KIF5 Antibody is an antibody against KIF5 for use in western blotting, ICC & immunofluorescence.
Key Applications
Western Blotting
Immunocytochemistry
Immunofluorescence
Application Notes
Immunocytochemistry Analysis: 5 μg/mL from a representative lot detected KIF5 in K562 cells.
Immunofluorescence Analysis: 20 μg/mL from a representative lot detected KIF5 in K562 cells.
Biological Information
Immunogen
KLH-conjugated synthetic peptide corresponding to the C-terminus of human KIF5.
Epitope
C-terminus
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Rabbit
Specificity
This antibody recognizes all isoforms of KIF5.
Species Reactivity
Human
Antibody Type
Polyclonal Antibody
Gene Symbol
KIF5A
NKHC1
Purification Method
Affinity
UniProt Number
Q12840
Molecular Weight
~116 kDa observed. Uncharacterized bands may be observed in some lysate(s).
Product Usage Statements
Quality Assurance
Evaluated by Western Blotting in K562 cell lysate.
Western Blotting Analysis: 1 μg/mL of this antibody detected KIF5 in K562 cell lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
