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Millipore Anti-Tresk Antibody Is An Antibody Against Tresk For Use In Western Blotting, Ihc & Immunofluorescence. - Mill (Additional S&H or Hazmat Fees May Apply)
Potassium channel subfamily K member 18, also known as TWIK-related individual potassium channel or TWIK-related spinal cord potassium channel, and encoded by the gene name KCNK18 or TRESK or TRIK, is a two-pore domain K+ channel that induces outward rectification and functions as a background K+ channel that is abundantly expressed in the spinal cord, thymus, spleen, and leukemic Tlymphocytes. TRESK is activated by increased cytoplasmic calcium concentration through calcineurin as well as by acetylcholine and histamine. TRESK may play a role in the regulation of T-cell function and could be an excellent target to treat T-cell originated immune dysfunction. Mutations in TRESK have been assoicated with migraine with or without aura 13.
Product Information
Format
Affinity Purified
Presentation
Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Quality Level
MQ100
Applications
Application
Anti-TRESK Antibody is an antibody against TRESK for use in western blotting, IHC & immunofluorescence.
Key Applications
Western Blotting
Immunohistochemistry
Immunofluorescence
Application Notes
Immunohistochemistry Analysis: 5 μg/mL from a representative lot detected TRESK in rat brain tissue.
Immunofluorescence Analysis: 20 μg/mL from a representative lot detected TRESK in rat brain cells.
Biological Information
Immunogen
KLH-conjugated synthetic peptide corresponding to the center region of human TRESK.
Epitope
center region
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Rabbit
Species Reactivity
Rat
Antibody Type
Polyclonal Antibody
Gene Symbol
KCNK18
TRESK
TRIK
Purification Method
Antigen Affinity Purified
UniProt Number
Q7Z418
Molecular Weight
~40 kDa observed. Uncharacterized bands may be observed in some lysate(s).
Product Usage Statements
Quality Assurance
Evaluated by Western Blotting in Rat brain tissue lysate.
Western Blotting Analysis: 2 μg/mL of this antibody detected TRESK in Rat brain tissue lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
