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Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H | WB, IHC | Rb | Affinity Purified | Polyclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | ABN415 |
| Description | Anti-TRAPPC1 Antibody |
| Alternate Names |
|
| Background Information | TRAPPC1 is one part of a larger protein complex called the TRAPP (transport protein particle) complex vital to Golgi function and transport. TRAPPC1 is localized to the Golgi and endoplasmic reticulum. Vesicle-mediated transport is a process carried out by virtually all cells and is required for the proper targeting and secretion of proteins. As such, there are numerous proteins involved to ensure that the proteins are properly transported, targeted, tethered, and localized. The TRAPP complex is just one such complex but it is one of the most studied. Mutations in TRAPPC proteins can lead to serious disorders including muscular dystrophy and myopathy such as that seen with mutations associated with TRAPPC11 (a related gene to TRAPPC1). |
| Product Information | |
|---|---|
| Format | Affinity Purified |
| Presentation | Purified rabbit Polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | This Anti-TRAPPC1 Antibody is validated for use in Western Blotting and Immunohistochemistry for the detection of TRAPPC1. |
| Key Applications |
|
| Application Notes | Western Blotting Analysis: 0.25 µg/mL from a representative lot detected TRAPPC1 in 5 µg of mouse brain tissue lysate. Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected TRAPPC1 in human cerebral cortex, cerebellum, and kidney. |
| Biological Information | |
|---|---|
| Immunogen | KLH-conjugated linear peptide corresponding to the Near C-terminus of Human TRAPPC1. |
| Epitope | Near C-terminus |
| Concentration | Please refer to lot specific datasheet. |
| Host | Rabbit |
| Species Reactivity |
|
| Species Reactivity Note | Human. Predicted to react with Monkey based on 100% sequence homology. |
| Antibody Type | Polyclonal Antibody |
| Entrez Gene Number |
|
| Gene Symbol |
|
| Purification Method | Antigen Affinity Purified |
| UniProt Number |
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| Molecular Weight | ~19 kDa observed. The endogenous band appears at ~31kDa (mouse brain) while the transfected band appears at ~19kDa |
| Product Usage Statements | |
|---|---|
| Quality Assurance | Evaluated by Western Blotting in TRAPPC1 transfected HEK293T cell lysate. Western Blotting Analysis: 0.25 µg/mL of this antibody detected TRAPPC1 in 5 µg of TRAPPC1 transfected HEK293T cell lysate. |
| Usage Statement |
|
| Storage and Shipping Information | |
|---|---|
| Storage Conditions | Stable for 1 year at 2-8°C from date of receipt. |
| Packaging Information | |
|---|---|
| Material Size | 100 µg |