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Millipore Anti-Irak-2 Antibody Is A Highly Specific Rabbit Polyclonal Antibody, That Targets Irak2 & Has Been Tested In Western Blotting, Icc & Immunofluorescence. - Mill (Additional S&H or Hazmat Fees May Apply)
Interleukin-1 receptor-associated kinase-like 2 (IRAK-2) binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. IRAK-2 also mediates activation of NF-κB, which is a pivotal transcription factor mediating inflammatory and immune response. Additionally, IRAK-2 may play an important role in IL-1R and TLR mediated inflammatory response. IRAK-2 is expressed in spleen, thymus, prostate, lung, liver, skeletal muscle, kidney, pancreas and peripheral blood leukocytes.
Product Information
Format
Affinity Purified
Control
HeLa and K562 cell lysates
Presentation
Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Quality Level
MQ100
Applications
Application
Anti-IRAK-2 Antibody is a highly specific rabbit polyclonal antibody, that targets IRAK2 & has been tested in western blotting, ICC & Immunofluorescence.
Key Applications
Western Blotting
Immunocytochemistry
Immunofluorescence
Application Notes
Immunocytochemistry Analysis: 2 µg/mL from a representative lot detected IRAK-2 in HeLa cells.
Immunofluorescence Analysis: 10 µg/mL from a representative lot detected IRAK-2 in HeLa cells.
Biological Information
Immunogen
KLH-conjugated linear peptide corresponding to human IRAK-2.
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Rabbit
Species Reactivity
Human
Antibody Type
Polyclonal Antibody
Gene Symbol
IRAK2
Purification Method
Antigen Affinity Purified
UniProt Number
O43187
Molecular Weight
~65 kDa observed. Uncharacterized bands may appear in some lysate(s).
Product Usage Statements
Quality Assurance
Evaluated by Western Blot in HeLa and K562 cell lysates.
Western Blot Analysis: 2 µg/mL of this antibody detected IRAK-2 in 15 µg of HeLa and K562 cell lysates.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
