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Millipore Anti-Pcbp4 Antibody Is A Highly Specific Rabbit Polyclonal Antibody, That Targets Poly (Rc) Binding Protein 4 & Has Been Tested In Western Blotting, Icc & Immunofluorescence. - Mill (Additional S&H or Hazmat Fees May Apply)
PCBP4 (also known as MCG10, Poly (rC) binding protein 4 and alpha-CP4) is a member of the KH-domain RNA-binding protein family. Proteins of this family also referred to as alpha-CPs, bind to RNA with specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. PCBP4 is induced by p53 and DNA damage via two p53-responsive promoter elements. Its overexpression in transfected cells results in the suppression of cell proliferation by inducing apoptosis and cell cycle arrest in G2-M. Decreased expression of one isoform of PCBP4 has been observed in many forms of lung cancer, leading to speculation that PCBP4 can act as a tumor suppressor.
Product Information
Format
Affinity Purified
Presentation
Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Quality Level
MQ100
Applications
Application
Anti-PCBP4 Antibody is a highly specific rabbit polyclonal antibody, that targets Poly (rC) binding protein 4 & has been tested in western blotting, ICC & Immunofluorescence.
Key Applications
Western Blotting
Immunocytochemistry
Immunofluorescence
Application Notes
Immunocytochemistry Analysis: 1 μg/mL from a representative lot detected PCBP4 in HeLa cells.
Immunofluorescence Analysis: 20 μg/mL from a representative lot detected PCBP4 in HeLa cells.
Biological Information
Immunogen
KLH-conjugated linear peptide corresponding to a 17 amino acid peptide near the C-terminus of human PCBP4.
Epitope
C-terminus
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Rabbit
Species Reactivity
Human
Antibody Type
Polyclonal Antibody
Gene Symbol
PCBP4
Purification Method
Antigen Affinity Purified
UniProt Number
P57723
Molecular Weight
~51 kDa observed. Uncharacterized bands may be observed in some lysate(s).
Product Usage Statements
Quality Assurance
Evaluated by Western Blotting in HeLa cell lysate.
Western Blotting Analysis: 2 μg/mL of this antibody detected PCBP4 in HeLa cell lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
