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Millipore This Anti-Foxl2 Antibody Is Validated For Use In Western Blotting For The Detection Of Foxl2. - Mill (Additional S&H or Hazmat Fees May Apply)
Forkhead box protein L2 (FOXL2) is a fork-head transcription factor that is expressed in developing gonad and in granulosa cells of the mature ovary. It plays a role in repressing the development of testis, and facilitating the differentiation and maintenance of the ovary. Mutations in the FOXL2 gene result in blepharophimosis ptosis epicanthus inversus (BPES) syndrome, which is characterized by craniofacial defects and premature ovarian failure. FOXL2 has also been implicated in the development of ovarian granulosa cell tumors.
Product Information
Format
Affinity Purified
Control
Human pituitary
Presentation
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
This Anti-FOXL2 Antibody is validated for use in Western Blotting for the detection of FOXL2.
Key Applications
Western Blotting
Biological Information
Immunogen
KLH-conjugated linear peptide corresponding to human FOXL2.
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Rabbit
Species Reactivity
Human
Species Reactivity Note
Demonstrated to react with Human. Predicted to react with Mouse, Bovine, Porcine, and Rabbit based on 100% sequence homology. Other homologies: Chicken (77% sequence homology).
Antibody Type
Polyclonal Antibody
Entrez Gene Number
NP_075555
Gene Symbol
FOXL2
Purification Method
Affinity Purfied
UniProt Number
P58012
Molecular Weight
~50 kDa observed. An uncharacterized band may appear at ~25 kDa in some lysates. The calculated molecular weight is 39 kDa, however FOXL2 has been shown as a ~50 kDa band in western blots (Marongiu, M., et al. (2010). PLOS One. 5(3):1-9).
Product Usage Statements
Quality Assurance
Evaluated by Western Blot in human pituitary tissue lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected FOXL2 in 10 µg of human pituitary tissue lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
