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DSS-AHC critical region on the X chromosome protein 1
Nuclear receptor DAX-1
AHC
Background Information
Dax-1 is an orphan nuclear receptor and is required for the normal development of the hypothalamic-pituitary-adrenal-gonadal axis formation. Defects in Dax-1 are the cause of X-linked adrenal hypoplasia congenital (XL-AHC); also known as X-linked Addison disease (AHX). Dax-1 also has a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency by acting as a negative regulator of Oct3/4 in ES cells.
Product Information
Format
Affinity Purified
Control
Dax1 overexpressing HEK293 transfected cell line
Presentation
Purified rabbit polyclonal serum in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
This Dax1 antibody is validated for use in WB & IHC for the detection of the Dax1 protein.
Key Applications
Western Blotting
Immunohistochemistry (Paraffin)
Application Notes
Evaluated by Immunohistochemistry in Human and Rat adrenal gland tissue. Immunohistochemsitry Analysis: A 1:1000 dilution of this antibody detected Dax1 in Human and Rat glioblastoma adrenal gland tissue.
Biological Information
Immunogen
KLH-conjugated linear peptide corresponding to the Region of Ligand binding of Human Dax1.
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Rabbit
Species Reactivity
Human
Rat
Species Reactivity Note
Demonstrated to react with Human and Rat Dax1. 75% Homologogous to Mouse Dax1
Antibody Type
Polyclonal Antibody
Entrez Gene Number
NP_000466
Gene Symbol
NR0B1
DAX1
AHC
Purification Method
Antigen Affinity Purified
UniProt Number
P51843
Molecular Weight
~53 kDa observed
Product Usage Statements
Quality Assurance
Evaluated by Western Blot in a Dax1 overexpressing HEK293 transfected cell line. Western Blot Analysis: A 1:2000 dilution of this antibody detected Dax1 in a Dax1 overexpressing HEK293 transfected cell line.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
