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Millipore Detect Phox2a Using This Rabbit Polyclonal Antibody, Anti-Phox2b Antibody Validated For Use In Western Blotting. - Mill (Additional S&H or Hazmat Fees May Apply)
Paired mesoderm homeobox protein 2B (PHOX2B), also known as Neuroblastoma Phox (NBPhox), PHOX2B homeodomain protein, and Paired-like homeobox 2B is a paired-homeodomain transcription factor that maintains the noradrenergic phenotype during embryogenesis. PHOX2 proteins help regulate endogenous hydroxylases in neural crest cells and aid in sympathetic neuron generation. PHOX2A controls only the differentiation of the main noradrenergic center of the human brain, while PHOX2B is required for the differentiation of all central and nonperipheral noradrenergic centers. PHOX2B is expressed in neuroblastoma, brain and adrenal gland. PHOX2B defects can cause congenital central hypoventilation syndrome (CCHS) and susceptibility to neuroblastoma type 2 (NBLST2). PHOX2 regulation may have therapeutic potential in aging or degenerative noradrenergic neuron disorders.
Product Information
Format
Affinity Purified
Control
HEK293 cell lysate
Presentation
Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Quality Level
MQ100
Applications
Application
Detect Phox2a using this rabbit polyclonal antibody, Anti-PHOX2B Antibody validated for use in western blotting.
Key Applications
Western Blotting
Biological Information
Immunogen
KLH-conjugated linear peptide corresponding to human PHOX2B.
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Rabbit
Species Reactivity
Human
Antibody Type
Polyclonal Antibody
Gene Symbol
PHOX2B
Purification Method
Antigen Affinity Purified
UniProt Number
Q99453
Molecular Weight
~22 kDa observed. Uncharacterized bands may appear in some lysate(s).
Product Usage Statements
Quality Assurance
Evaluated by Western Blotting in HEK293 cell lysate.
Western Blotting Analysis: 2 µg/mL of this antibody detected PHOX2B in 15 µg of HEK293 cell lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
