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Millipore Anti-Sec62 Antibody Detects Level Of Sec62 & Has Been Published & Validated For Use In Sec62. - Mill (Additional S&H or Hazmat Fees May Apply)
Translocation protein SEC62, also known as Translocation protein 1 (TP-1) or (hTP-1), and encoded by the gene name SEC62, is an integral membrane protein located in the rough endoplasmic reticulum (ER) and is part of the SEC61-SEC62-SEC63 complex. This complex is the central component of the protein translocation apparatus of the ER membrane. It is speculated that SEC61-SEC62-SEC63 may perform post-translational protein translocation into the ER and might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. Silencing of this gene with RNAi dramatically reduced the migration and invasive potential of numerous tumor cell lines, suggesting that it may be an attractive target for therapy of various tumors.
Product Information
Format
Affinity Purified
Presentation
Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Quality Level
MQ100
Applications
Application
Anti-SEC62 Antibody detects level of SEC62 & has been published & validated for use in SEC62.
Key Applications
Western Blotting
Immunohistochemistry
Application Notes
Immunohistochemistry Analysis: 5 μg/mL from a representative lot detected SEC62 in mouse brain tissue.
Biological Information
Immunogen
KLH-conjugated synthetic peptide corresponding to the C-terminus of human SEC62.
Epitope
C-terminus
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Rabbit
Specificity
This antibody is predicted to not cross-react with other SEC proteins.
Species Reactivity
Rat
Mouse
Antibody Type
Polyclonal Antibody
Gene Symbol
SEC62
TLOC1
Purification Method
Antigen Affinity Purified
UniProt Number
Q99442
Molecular Weight
~31 and ~43 kDa observed. Uncharacterized bands may be observed in some lysate(s).
Product Usage Statements
Quality Assurance
Evaluated by Western Blotting in rat brain tissue lysate.
Western Blotting Analysis: 0.5 μg/mL of this antibody detected SEC62 in rat brain tissue lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
