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Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H, R | WB, IH(P) | Rb | Affinity Purified | Polyclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | ABC244 |
| Description | Anti-PATE1 Antibody |
| Alternate Names |
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| Background Information | PATE1 is a secreted protein that is expressed exclusively in the prostate and testis and is up regulated in the prostate epithelial cells during cancer. Because of the extreme specificity of PATE1 expression it makes it a potential target for immunotherapy in prostate cancer. PATE1 is the founding member of new syntenic loci in humans and mice that encode secreted proteins that have 10 cysteine residues. The PATE family has three-fingered protein/Ly-6/urokinase-type plasminogen activator receptor (uPAR) domains that shape three-fingered proteins (TFPs). Additional members include PATE-M, PATE-DJ, and PATE-B that are also expressed in prostate and testis and sperm. Related proteins, PATE-P and PATE-Q are expressed only in placenta. Research indicates that PATE proteins may have something to do with fertility and recent research showed that addition PATE-like genes were expressed in neuron-rich tissues and thus may have a role in neurological function or transmission. |
| Product Information | |
|---|---|
| Format | Affinity Purified |
| Presentation | Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | This Anti-PATE1 Antibody is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of PATE1. |
| Key Applications |
|
| Application Notes | Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected PATE1 in human testis and human hyperplastic prostate tissue. |
| Biological Information | |
|---|---|
| Immunogen | GST-tagged recombinant protein corresponding to human PATE1. |
| Concentration | Please refer to lot specific datasheet. |
| Host | Rabbit |
| Species Reactivity |
|
| Species Reactivity Note | Human, Rat. Predicted to react with mouse based on 70% sequence homology. |
| Antibody Type | Polyclonal Antibody |
| Entrez Gene Number |
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| Gene Symbol |
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| Purification Method | Affinity Purfied |
| UniProt Number |
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| Molecular Weight | ~14 kDa observed |
| Product Usage Statements | |
|---|---|
| Quality Assurance | Evaluated by Western Blotting in rat testis tissue lysate. Western Blotting Analysis: A 1:500 dilution of this antibody detected PATE1 in 10 µg of rat testis tissue lysate. |
| Usage Statement |
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| Storage and Shipping Information | |
|---|---|
| Storage Conditions | Stable for 1 year at 2-8°C from date of receipt. |
| Packaging Information | |
|---|---|
| Material Size | 100 µL |