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Millipore Anti-Annexin A1 Is An Antibody Targeting The Annexin A1 Protein, Validated For Use In Wb & Ihc. - Mill (Additional S&H or Hazmat Fees May Apply)
Annexin A1 (ANXA1) is a calcium and phospholipid binding protein almost entirely restricted to microglia in the CNS. During the peripheral inflammatory response, Annexin A1 is instrumental in the phagocytosis of apoptotic leukocytes. Annexin A1 restores the ability of microglia to differentiate between apoptotic and non-apoptotic cells during inflammatory activation. Current research is geared towards using Annexin A1 as a therapeutic target in neuroinflammation. Annexin A1 has also been shown to be influential in cancer development and proliferation.
Product Information
Format
Purified
Control
L6 cell lysate
Presentation
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
Anti-Annexin A1 is an antibody targeting the Annexin A1 protein, validated for use in WB & IHC.
Key Applications
Western Blotting
Immunohistochemistry
Application Notes
Western Blot Analysis: 2.0 µg/mL from a representative lot detected Annexin A1 in 10 µg of C2C12, HUVEC, and NIH/3T3 cell lysate. Immunohistochemistry Analysis: 1:500 dilution from a representative lot detected Annexin A1 in human lung tissue.
Biological Information
Immunogen
KLH-conjugated linear peptide corresponding to the C-terminus of human Annexin A1.
Epitope
C-terminus
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Rabbit
Specificity
This antibody recognizes the C-terminus of Annexin A1
Species Reactivity
Human
Mouse
Rat
Porcine
Chimpanzee
Bovine
Species Reactivity Note
Demonstrated to react with Human, Mouse, and Rat. Predicted to react with Porcine, Chimpanzee, and Bovine based on 100% sequence homology.
Antibody Type
Polyclonal Antibody
Entrez Gene Number
NP_000691
Gene Symbol
ANXA1
ANX1
LPC1
Purification Method
Protein A Purfied
UniProt Number
P04083
Molecular Weight
~38 kDa observed
Product Usage Statements
Quality Assurance
Evaluated by Western Blot in L6 cell lysate.
Western Blot Analysis: 2.0 µg/mL of this antibody detected Annexin A1 in 10 µg of L6 cell lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
