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TRP (transient receptor potential)-related ion channels (TRPCs) have been postulated as candidates for forming both receptor-operated (ROCE) and capacitative Ca2+ entry channels across the plasma membrane. ER transmembrane protein STIM1 senses the depletion of Ca2+ from ER stores. Orai proteins, interacting with TRPCs, act as regulatory subunits that confers STIM1-mediated store depletion sensitivity to these channels and regulate Ca2+ influx through the plasma membrane.
Product Information
Format
Purified
Control
Jurkat lysate.
Presentation
Purified in PBS with 0.05% NaN3
Quality Level
MQ100
Applications
Application
Anti-STIM1 Antibody is an antibody against STIM1 for use in WB.
Key Applications
Western Blotting
Application Notes
Optimal working dilutions must be determined by the end user.
Biological Information
Immunogen
Synthetic Linear Peptide
Host
Rabbit
Specificity
Catalogue No. AB9870 recognizes the C-Terminus of STIM1.
Species Reactivity
Human
Mouse
Antibody Type
Polyclonal Antibody
Gene Symbol
CAV1
NUP98
ORAI1
ORAI2
Purification Method
Protein A Purfied
UniProt Number
Q13586
Molecular Weight
80 kDa
Product Usage Statements
Quality Assurance
Routinely evaluated in western blotting using Jurkat lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.
