The store will not work correctly when cookies are disabled.
We use cookies to make your experience better.To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
Millipore Anti-Cannabinoid Receptor 1 Antibody Detects Level Of Cannabinoid Receptor 1 & Has Been Published & Validated For Use In Ic, Ih(P). - Mill (Additional S&H or Hazmat Fees May Apply)
Affinity purified immunoglobulin. Liquid in PBS, with less than 0.1% sodium azide.
Quality Level
MQ100
Applications
Application
Anti-Cannabinoid Receptor 1 Antibody detects level of Cannabinoid Receptor 1 & has been published & validated for use in IC, IH(P).
Key Applications
Immunocytochemistry
Immunohistochemistry (Paraffin)
Application Notes
Immunohistochemistry on formalin fixed paraffin embedded tissue sections.
Immunocytochemistry on acetone fixed cells.
Optimal working dilutions must be determined by the end user.
Biological Information
Immunogen
Synthetic peptide from the 3rd cytoplasmic domain of human Cannabinoid Receptor 1. The immunogen sequence has 100% homology with mouse.
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Rabbit
Specificity
Recognizes Cannabinoid Receptor 1 [CB1].
Species Reactivity
Human
Monkey
Rat
Antibody Type
Polyclonal Antibody
Entrez Gene Number
NM_016083.3
NM_033181.2
Entrez Gene Summary
This gene encodes a protein that is one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the family of guanine-nucleotide-binding protein (G-protein) coupled receptors which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Two transcript variants encoding different isoforms have been described for this gene.
Gene Symbol
CNR1
CNR
CB1K5
CANN6
CB1A
CB-R
CB1
UniProt Number
P21554
UniProt Summary
FUNCTION: SwissProt: P21554 # Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Isoform 2 and isoform 3 have altered ligand binding. SIZE: 472 amino acids; 52858 Da SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Widely expressed. SIMILARITY: SwissProt: P21554 ## Belongs to the G-protein coupled receptor 1 family.
Product Usage Statements
Availability by Geography
This product is not available for sale in Japan.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Maintain at -70°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
