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GCM1 is a DNA binding protein with a GCM motif (glial cell missing motif) that is a key transcription factor for determining the fate of stem cells within the nervous system, in addition to being critical for placental development. This protein binds to the GCM motif (A/G)CCCGCAT, a novel sequence among known targets of DNA binding proteins. The N-terminal DNA-binding domain confers the unique DNA binding activity of this protein. Current studies indicate that the introduction of the mouse GCM1 gene in cultured cells from embryonic brains resulted in the induction of an astrocyte lineage.
Product Information
Format
Affinity Purified
Presentation
Purified rabbit polyclonal antibody in buffer containing PBS with 0.09% sodium azide.
Quality Level
MQ100
Applications
Application
This Anti-mGCM1 Antibody is validated for use in WB for the detection of mGCM1.
Key Applications
Western Blotting
Biological Information
Immunogen
Synthetic GCM1 peptide, a.a. 401-418.
Epitope
C-terminus
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Rabbit
Specificity
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptided selected from the C-terminal region mouse GCM1.
Species Reactivity
Human
Species Reactivity Note
Reacts with human. Comparison of sequence homology suggests that this antibody will also react in mouse and rat; however, reactivity to other species has not been tested.
Antibody Type
Polyclonal Antibody
Entrez Gene Number
P70348
Gene Symbol
GCMa
glide
Gcm-rs2
Gcm1-rs1
Gcm1
hGCMa
Purification Method
Peptide affinity purified
UniProt Number
P70348
Stem Cell Type
Neural Stem Cells
Pancreatic Stem Cells
Molecular Weight
50 kDa
Product Usage Statements
Quality Assurance
Routinely evaluated by western blot on HEK-293 lysates.
Western Blotting: Recommended working dilutions are 1:1000 – 1:2500.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months. Avoid repeat freeze/thaw cycles.
