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Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| Ch, H, M, R | ELISA, WB, IHC, FUNC | Sh | Purified | Polyclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | AB1528SP |
| Replaces | 04-1119 |
| Brand Family | Chemicon® |
| Trade Name |
|
| Description | Anti-Nerve Growth Factor-β Antibody |
| Alternate Names |
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| Product Information | |
|---|---|
| Format | Purified |
| Presentation | Protein G purified immunoglobulin. Lyophilized from PBS, no preservatives. Reconstitute with 500 μL of sterile distilled water (1 mg/mL). |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | Anti-Nerve Growth Factor-β Antibody is an antibody against Nerve Growth Factor-β for use in ELISA, WB, IH. |
| Key Applications |
|
| Application Notes | Immunohistochemistry: 1-10 μg/mL (see suggested protocol). Immunoblotting: 1-10 μg/mL ELISA: 1-10 μg/mL Inhibition of biological activity in vitro: 1-10 μg/mL BIOLOGICAL ACTIVITY: Neutralizes NGF, but not other neurotrophins. Optimal working dilutions must be determined by the end user. |
| Biological Information | |
|---|---|
| Immunogen | Mouse nerve growth factor-beta purified from salivary glands. Antigen purity greater than 95% by PAGE. |
| Host | Sheep |
| Specificity | Nerve growth factor-beta (NGF). By one site ELISA, less than 1% cross-reactivity against recombinant human BDNF or neurotrophin 4. Approximately 2% cross-reactivity against neurotrophin 3. |
| Species Reactivity |
|
| Antibody Type | Polyclonal Antibody |
| Entrez Gene Number |
|
| Entrez Gene Summary | This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this genes expression is associated with allergic rhinitis. |
| Gene Symbol |
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| Non-Reactive Species |
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| UniProt Number |
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| UniProt Summary | FUNCTION: SwissProt: P01138 # Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. It stimulates division and differentiation of sympathetic and embryonic sensory neurons. SIZE: 241 amino acids; 26959 Da SUBUNIT: Homodimer. SUBCELLULAR LOCATION: Secreted. DISEASE: SwissProt: P01138 # Defects in NGFB are the cause of hereditary sensory and autonomic neuropathy type 5 (HSAN5) [MIM:608654]. Hereditary sensory and autonomic neuropathies are characterized by loss of pain sensation in combination with other sensory and/or autonomic abnormalities. HSAN5 patients manifest loss of pain perception and impaired temperature sensitivity, ulcers, and in some cases self- mutilation. The autonomic involvement is variable. SIMILARITY: SwissProt: P01138 ## Belongs to the NGF-beta family. |
| Product Usage Statements | |
|---|---|
| Usage Statement |
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| Storage and Shipping Information | |
|---|---|
| Storage Conditions | Maintain at -20 to -70°C in undiluted aliquots for up to one year. Avoid repeated freeze/thaw cycles. Glycerol (1:1) can be added for additional stability. |
| Packaging Information | |
|---|---|
| Material Size | 500 µg |