| Description | |
|---|---|
| Catalogue Number | 12-547 |
| Brand Family | Upstate |
| Trade Name |
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| Description | JAK3tide |
| Product Information | |
|---|---|
| Presentation | lyophilized |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | JAK3tide primarily used in Kinase Assays. |
| Key Applications |
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| Biological Information | |
|---|---|
| Entrez Gene Number |
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| Entrez Gene Summary | JAK3 encodes Janus kinase 3, a tyrosine kinase that belongs to the Janus family. JAK3 functions in signal transduction and interacts with members of the STAT (signal transduction and activators of transcription) family. JAK3 is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations that abrogate Janus kinase 3 function cause an autosomal SCID (severe combined immunodeficiency disease). |
| Gene Symbol |
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| Protein Target | JAK3 |
| Target Sub-Family | TK |
| UniProt Number |
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| UniProt Summary | FUNCTION: SwissProt: P52333 # Tyrosine kinase of the non-receptor type, involved in the interleukin-2 and interleukin-4 signaling pathway. Phosphorylates STAT6, IRS1, IRS2 and PI3K. SIZE: 1124 amino acids; 125099 Da SUBUNIT: Interacts with STAM2 and MYO18A (By similarity). Interacts with SHB. SUBCELLULAR LOCATION: Intracytoplasmic membrane; Peripheral membrane protein (By similarity). Note=Wholly intracellular, possibly membrane associated (By similarity). TISSUE SPECIFICITY: In NK cells and an NK-like cell line but not in resting T-cells or in other tissues. The S-form is more commonly seen in hematopoietic lines, whereas the B- and M-forms are detected in cells both of hematopoietic and epithelial origins. DOMAIN: SwissProt: P52333 Possesses two phosphotransferase domains. The second one probably contains the catalytic domain (By similarity), while the presence of slight differences suggest a different role for domain 1. PTM: Tyrosine phosphorylated in response to IL-2 and IL-4. DISEASE: SwissProt: P52333 # Defects in JAK3 are a cause of autosomal recessive T-cell negative/B-cell positive type of severe combined immunodeficiency (SCID) [MIM:600802]; a condition characterized by the absence of circulating mature T-lymphocytes and NK cells, normal to elevated numbers of nonfunctional B-lymphocytes, and marked hypoplasia of lymphoid tissues. SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily. & Contains 1 FERM domain. & Contains 1 protein kinase domain. & Contains 1 SH2 domain. |
| Product Usage Statements | |
|---|---|
| Quality Assurance | Routinely evaluated as a substrate using JAK3, active (14-629) |
| Usage Statement |
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| Storage and Shipping Information | |
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| Storage Conditions | 2 years at 4°C |
| Packaging Information | |
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| Material Size | 1000 µg |