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Millipore Detect Dimethyl-Arginine Using This Anti-Dimethyl-Arginine Antibody, Asymmetric (Asym25) Validated For Use In Wb. - Mill (Additional S&H or Hazmat Fees May Apply)
Asymmetrical dimethlarginine (ADMA) is an endogenous, L-arginine metabolite arising from the proteolysis of methylated arginine containing proteins and is a known inhibitor of nitric oxide synthase (NOS). In various studies, ADMA has been observed as having a regulatory role in cell motility and the actin cytoskeleton. Elevated levels of ADMA are associated with sporadic FSGS, coronary artery disease, hypertension, peripheral arterial occlusive disease, obesity, stroke, preeclampsia, and cardiovascular mortality/morbidity in patients with diabetic nephropathy.
Product Information
Format
Serum
Control
PRMT1 treated and untreated MEF cell lysates
Presentation
Unpurified rabbit polyclonal containing serum with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
Detect dimethyl-Arginine using this Anti-dimethyl-Arginine Antibody, asymmetric (ASYM25) validated for use in WB.
Key Applications
Western Blotting
Biological Information
Immunogen
KLH-conjugated linear peptide containing asymmetric dimethyl-arginine-glycine repeats.
Epitope
Unknown
Host
Rabbit
Specificity
This antibody recognizes dimethylated arginines.
Species Reactivity
Mouse
Human
Rat
Species Reactivity Note
Demonstrated to react with mouse. Predicted to react with human and rat based on 100% sequence homology.
Antibody Type
Polyclonal Antibody
Gene Symbol
ASYM25
ADMA
Purification Method
Unpurified
Molecular Weight
Multiple. This antibody detects proteins containing asymmetrical dimethylated arginines.
Product Usage Statements
Quality Assurance
Evaluated by Western Blot in PRMT1 treated and untreated MEF cell lysates.
Western Blot Analysis: 1:1,000 dilution of this antibody detected dimethyl-Arginine on 10 µg of PRMT1 treated and untreated MEF cell lysates.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
