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Millipore Detect Rea With Anti-Rea Antibody (Rabbit Polyclonal Antibody), That Has Been Shown To Work In Ip, Wb, Icc. - Mill (Additional S&H or Hazmat Fees May Apply)
200 μg of protein A purified rabbit IgG in 200 μL of 0.07 M Tris-glycine, pH 7.4, 0.105M NaCl, 0.035% sodium azide and 30% glycerol.
Quality Level
MQ100
Applications
Application
Detect REA with Anti-REA Antibody (Rabbit Polyclonal Antibody), that has been shown to work in IP, WB, ICC.
Key Applications
Immunoprecipitation
Western Blotting
Immunocytochemistry
Biological Information
Immunogen
His6-tagged fusion protein corresponding to amino acid residues 88-299 of mouse REA-1/BAP-37/prohibitin-related protein
Host
Rabbit
Specificity
REA
Isotype
IgG
Species Reactivity
Human
Mouse
Rat
Antibody Type
Polyclonal Antibody
Entrez Gene Number
NM_007273
Gene Symbol
PHB2
BCAP37
BAP
Prohibitin-2
REA
D-prohibitin
PNAS-141
MGC117268
p22
Bap37
Purification Method
Protein A chromatography
UniProt Number
Q99623
UniProt Summary
FUNCTION: SwissProt: Q99623 # Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging. SIZE: 299 amino acids; 33296 Da SUBUNIT: Interacts with PHB, ESR1, HDAC1 and HDAC5 (By similarity). SUBCELLULAR LOCATION: Mitochondrion inner membrane (By similarity). Cytoplasm (By similarity). Nucleus (By similarity). Note=Also cytoplasmic and nuclear (By similarity). DEVELOPMENTAL STAGE: Levels of expression in fibroblasts decrease heterogeneously during cellular aging. SIMILARITY: SwissProt: Q99623 ## Belongs to the prohibitin family.
Molecular Weight
37kDa
Product Usage Statements
Quality Assurance
routinely evaluated by immunoblot on 3T3 nuclear extract
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
