The store will not work correctly when cookies are disabled.
We use cookies to make your experience better.To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
Millipore Use Anti-Sox1 Antibody (Rabbit Polyclonal Antibody) Validated In Ihc(P) To Detect Sox1 Also Known As Sry (Sex Determining Region Y)-Box 1, Sry-Related Hmg-Box Gene 1. - Mill (Additional S&H or Hazmat Fees May Apply)
Sox-1 protein (SOX1), also known as SRY (Sex determining region Y)-box 1, is expressed in the developing brain. SOX1 is related to the HMG box of family transcription factors, which are a highly motile group, with a highly conserved DNA binding domain. Sox1 utilizes multiple pathways to play a direct role on cell fate. SOX1 is also directly involved with sex determination of the Y chromosome. Binding of the SOX1, C-terminus, to the Hes 1 promoter results in Hes1 suppression and attenuation of Notch signaling. When the C-terminus of SOX1 binds to β-catenin, TCF/LEF is suppressed, resulting in the attenuation of Wnt signaling.
Product Information
Format
Affinity Purified
Presentation
Purified rabbit polyclonal antibody precipitated in a solution of 50% saturated ammonium sulfate and PBS containing no preservatives.
Quality Level
MQ100
Applications
Application
Use Anti-SOX1 Antibody (Rabbit Polyclonal Antibody) validated in IHC(P) to detect SOX1 also known as SRY (sex determining region Y)-box 1, SRY-related HMG-box gene 1.
Key Applications
Immunohistochemistry (Paraffin)
Biological Information
Immunogen
Synthetic peptide corresponding to SOX1.
Host
Rabbit
Specificity
This antibody recognizes SOX1.
Species Reactivity
Mouse
Human
Species Reactivity Note
Human. Predicted to react with mouse based on sequence homology.
Antibody Type
Polyclonal Antibody
Entrez Gene Number
NM_009233
Gene Symbol
SOX1
SRY
Purification Method
Affinity Purfied
UniProt Number
O00570
UniProt Summary
FUNCTION: Transcriptional activator By similarity.
SUBCELLULAR LOCATION: NucleusProbable.
TISSUE SPECIFICITY: Mainly in the developing central nervous system.
Evaluated by immunohistochemistry on human epidermis.
Immunohistochemistry(paraffin): A 1:300 dilution of this antibody was used to detect SOX1 in human epidermis.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Stable for 1 year at 2-8ºC from date of receipt. To reconstitute the antibody, centrifuge the antibody at a moderate speed (5,000 rpm) for 5 minutes. Carefully remove the ammonium sulfate/PBS buffer solution and discard; 10 μL of residual ammonium sulfate solution will not affect the re-suspension of the antibody. Do not let the protein pellet dry, as severe loss of antibody reactivity can occur. Re-suspend the antibody pellet in 100L either standard PBS or TBS (pH 7.3-7.5). DO NOT VORTEX. Mix by gentle stirring with a wide pipet tip or gentle finger-tapping. Let the precipitated antibody rehydrate for 1 hour at 25°C prior to use. Small particles of precipitated antibody that fail to re-suspend are normal. Vials are overfilled to compensate for any losses.
