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Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| M | EMSA, IP, WB, ICC | Rb | Affinity Purified | Polyclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | 07-140 |
| Brand Family | Upstate |
| Trade Name |
|
| Description | Anti-STAT2 Antibody |
| Product Information | |
|---|---|
| Format | Affinity Purified |
| Presentation | 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30% |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | Anti-STAT2 Antibody is a Rabbit Polyclonal Antibody for detection of STAT2 also known as Signal Transducer & Activator of Transcription 2 & has been tested in EMSA, IP, WB, ICC. |
| Key Applications |
|
| Biological Information | |
|---|---|
| Immunogen | GST-fusion protein corresponding to residues 672-925 of murine STAT2 |
| Host | Rabbit |
| Specificity | STAT2 |
| Isotype | IgG |
| Species Reactivity |
|
| Antibody Type | Polyclonal Antibody |
| Entrez Gene Number |
|
| Entrez Gene Summary | The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. |
| Gene Symbol |
|
| Purification Method | Affinity Chromatography |
| UniProt Number |
|
| UniProt Summary | FUNCTION: SwissProt: P52630 # Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. SIZE: 851 amino acids; 97916 Da SUBUNIT: Interacts with ISGF3G/IRF-9 in the cytoplasm. Heterodimer with STAT1 upon IFN-alpha/beta induced phosphorylation. Interacts with CRSP2 and CRSP6. Interacts with Simian virus 5 protein V and rabies virus phosphoprotein (By similarity). SUBCELLULAR LOCATION: Cytoplasm. Note=Translocated into the nucleus upon activation by IFN-alpha/beta. PTM: Tyrosine phosphorylated in response to IFN-alpha. SIMILARITY: SwissProt: P52630 ## Belongs to the transcription factor STAT family. & Contains 1 SH2 domain. |
| Molecular Weight | 130kDa |
| Product Usage Statements | |
|---|---|
| Quality Assurance | routinely evaluated by immunoblot on |
| Usage Statement |
|
| Storage and Shipping Information | |
|---|---|
| Storage Conditions | 2 years at -20°C |
| Packaging Information | |
|---|---|
| Material Size | 200 µg |