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Millipore Detect Orc2 With Anti-Orc2 Antibody, Clone 3g6 (Rat Monoclonal Antibody), That Has Been Shown To Work In Ip & Wb. - Mill (Additional S&H or Hazmat Fees May Apply)
Detect ORC2 with Anti-ORC2 Antibody, clone 3G6 (Rat Monoclonal Antibody), that has been shown to work in IP & WB.
Key Applications
Immunoprecipitation
Western Blotting
Biological Information
Immunogen
Full-length human origin recognition complex 2 (ORC2). Clone 3G6.
Clone
clone 3G6
Host
Rat
Specificity
ORC2
Isotype
IgG2a
Species Reactivity
Human
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NP_006181
Entrez Gene Summary
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. This protein forms a core complex with ORC3L, -4L, and -5L. It also interacts with CDC45L and MCM10, which are proteins known to be important for the initiation of DNA replication. This protein has been demonstrated to specifically associate with the origin of replication of Epstein-Barr virus in human cells, and is thought to be required for DNA replication from viral origin of replication.
Gene Symbol
ORC2L
ORC2
Purification Method
Protein G Purified
UniProt Number
Q13416
UniProt Summary
FUNCTION: SwissProt: Q13416 # Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication in an ATP-dependent manner. SIZE: 577 amino acids; 65972 Da SUBUNIT: ORC is composed of six subunits. Interacts with DBF4 (By similarity). Interacts with MCM10. SUBCELLULAR LOCATION: Nucleus. SIMILARITY: SwissProt: Q13416 ## Belongs to the ORC2 family.
Molecular Weight
65-70kDa
Product Usage Statements
Quality Assurance
Routinely evaluated by immunoblot.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
