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Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H, M, R | ICC, WB | M | Purified | Monoclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | 05-832 |
| Brand Family | Upstate |
| Trade Name |
|
| Description | Anti-LKB1 Antibody, clone 5c10 |
| Product Information | |
|---|---|
| Format | Purified |
| Control |
|
| Presentation | Protein G Purified immunoglobulin in 0.1M Tris-Glycine, 0.15M NaCl and 0.05% Sodium Azide, pH 7.4. |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | This Anti-LKB1 Antibody, clone 5c10 is validated for use in IC, WB for the detection of LKB1. |
| Key Applications |
|
| Biological Information | |
|---|---|
| Immunogen | GST fusion protein corresponding to residues 1-433 of human LKB1 |
| Clone | 5c10 |
| Concentration | Please refer to the Certificate of Analysis for the lot-specific concentration. |
| Host | Mouse |
| Specificity | Recognizes LKB1. |
| Isotype | IgG |
| Species Reactivity |
|
| Antibody Type | Monoclonal Antibody |
| Entrez Gene Number |
|
| Entrez Gene Summary | This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. |
| Gene Symbol |
|
| Purification Method | Protein G Purified |
| UniProt Number |
|
| UniProt Summary | FUNCTION: SwissProt: Q15831 # Essential role in G1 cell cycle arrest. Phosphorylates and activates members of the AMPK-related subfamily of protein kinases. Tumor suppressor. COFACTOR: Magnesium or Manganese. SIZE: 433 amino acids; 48636 Da SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Relocates to the cytoplasm when bound to CAB39 and STRAD or CAB39 and ALS2CR2. TISSUE SPECIFICITY: Ubiquitously expressed. Strongest expression in testis and fetal liver. PTM: Phosphorylated by a cAMP-dependent protein kinase (By similarity). DISEASE: SwissProt: Q15831 # Defects in STK11 are a cause of Peutz-Jeghers syndrome (PJS) [MIM:175200]. PJS is a rare hereditary disease in which there is predisposition to benign and malignant tumors of many organ systems. PJS is an autosomal dominant disorder characterized by melanocytic macules of the lips, multiple gastrointestinal hamartomatous polyps and an increased risk for various neoplasms, including gastrointestinal cancer. & Defects in STK11 have been associated with testicular tumors [MIM:273300]. It includes germ cell tumor (GCT) or testicular germ cell tumor (TGCT). SIMILARITY: SwissProt: Q15831 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. & Contains 1 protein kinase domain. |
| Molecular Weight | 55 kDa |
| Product Usage Statements | |
|---|---|
| Quality Assurance | routinely evaluated by immunoblot on RIPA lysates from Rat2 cells |
| Usage Statement |
|
| Storage and Shipping Information | |
|---|---|
| Storage Conditions | Stable for 1 year at 2-8°C from date of receipt. |
| Packaging Information | |
|---|---|
| Material Size | 100 µg |