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Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H, M | WB, IHC | M | Purified | Monoclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | 05-579 |
| Brand Family | Upstate |
| Trade Name |
|
| Description | Anti-Endostatin Antibody, clone 1837.46 |
| Product Information | |
|---|---|
| Format | Purified |
| Presentation | 50mM sodium phosphate, pH 8.0, 0.05% sodium azide, before the addition of glycerol to 30% |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | Anti-Endostatin Antibody, clone 1837.46 is an antibody against Endostatin for use in WB, IH. |
| Key Applications |
|
| Biological Information | |
|---|---|
| Immunogen | Full-length recombinant murine endostatin |
| Clone | clone 1837.46 |
| Host | Mouse |
| Specificity | endostatin |
| Isotype | IgG |
| Species Reactivity |
|
| Antibody Type | Monoclonal Antibody |
| Entrez Gene Number |
|
| Entrez Gene Summary | This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. The proteolytically produced C-terminal fragment of type XVIII collagen is endostatin, a potent antiangiogenic protein. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Two transcript variants encoding different isoforms have been found for this gene. |
| Gene Symbol |
|
| Purification Method | Thiophilic chromatography |
| UniProt Number |
|
| UniProt Summary | FUNCTION: SwissProt: P39060 # Endostatin potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling. SIZE: 1754 amino acids; 178160 Da SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix (By similarity). TISSUE SPECIFICITY: Present in multiple organs with highest levels in liver, lung and kidney. PTM: Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. DISEASE: SwissProt: P39060 # Defects in COL18A1 are a cause of Knobloch syndrome (KNO) [MIM:267750]. KNO is an autosomal recessive disorder defined by the occurrence of high myopia, vitreoretinal degeneration with retinal detachment, macular abnormalities and occipital encephalocele. SIMILARITY: SwissProt: P39060 ## Belongs to the multiplexin collagen family. & Contains 1 FZ (frizzled) domain. & Contains 1 TSP N-terminal (TSPN) domain. |
| Molecular Weight | Recognizes endostatin, Mr 22kDa. An unidentified protein is also weakly detected at Mr 54kDa. |
| Product Usage Statements | |
|---|---|
| Quality Assurance | routinely evaluated by immunoblot on 3T3 cell lysates |
| Usage Statement |
|
| Storage and Shipping Information | |
|---|---|
| Storage Conditions | 2 years at -20°C |
| Packaging Information | |
|---|---|
| Material Size | 200 µL |