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Millipore Anti-P75ntr (Neurotrophin Receptor) Antibody, Clone Me20.4 Detects Level Of P75ntr (Neurotrophin Receptor) & Has Been Published & Validated For Use In Ip, Wb, Ih, Neut. - Mill (Additional S&H or Hazmat Fees May Apply)
0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Quality Level
MQ100
Applications
Application
Anti-p75NTR (Neurotrophin Receptor) Antibody, clone ME20.4 detects level of p75NTR (Neurotrophin Receptor) & has been published & validated for use in IP, WB, IH, NEUT.
Key Applications
Immunoprecipitation
Western Blotting
Immunohistochemistry
Neutralizing
Biological Information
Immunogen
Human melanoma cell line WM245.
Clone
A16/17
Host
Mouse
Specificity
low affinity p75NTR
Isotype
IgG1
Species Reactivity
Human
Monkey
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NM_002507
Entrez Gene Summary
Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain.
Gene Symbol
NGFR
Gp80-LNGFR
CD271
p75(NTR)
TNFRSF16
Purification Method
Protein G Chromatography
UniProt Number
P08138
UniProt Summary
FUNCTION: SwissProt: P08138 # Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. SIZE: 427 amino acids; 45183 Da SUBUNIT: Homodimer; disulfide-linked. Interacts with p75NTR- associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. DOMAIN: SwissProt: P08138 Death domain is responsible for interaction with RANBP9. PTM: N- and O-glycosylated. & O-linked glycans consist of Gal(1-3)GalNAc core elongated by 1 or 2 NeuNAc. & Phosphorylated on serine residues. SIMILARITY: Contains 1 death domain. & Contains 4 TNFR-Cys repeats.
Molecular Weight
69kDa
Product Usage Statements
Quality Assurance
routinely evaluated by immunoblot on RIPA lysates from HS294T cells
Sales Restrictions
Due to license agreement restrictions, this product cannot be purchased for resale.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
