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Millipore Anti-Avian Src Antibody, Clone Ec10 Detects Level Of Avian Src & Has Been Published & Validated For Use In Ip, Wb & Ic. - Mill (Additional S&H or Hazmat Fees May Apply)
0.1M Tris-glycine, pH 7.4, 0.15M NaCl, with 0.05% sodium azide
Quality Level
MQ100
Applications
Application
Anti-avian Src Antibody, clone EC10 detects level of avian Src & has been published & validated for use in IP, WB & IC.
Key Applications
Immunoprecipitation
Western Blotting
Immunocytochemistry
Biological Information
Immunogen
Recombinant chicken pp60src
Clone
clone EC10
Host
Mouse
Specificity
specific only for avian Src; this antibody is excellent for distinguishing pp60src in cells transfected with v-src or c-src expression vectors.
Isotype
IgG2b
Species Reactivity
Avian
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NM_005417.3
NM_198291.1
Entrez Gene Summary
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
Gene Symbol
SRC
c-src
p60-Src
SRC1
c-SRC
ASV
pp60c-src
Purification Method
Protein G Chromatography
UniProt Number
P12931
UniProt Summary
SIZE: 536 amino acids; 59835 Da SUBUNIT: Interacts with DDEF1/ASAP1 via its SH3 domain. Interacts with CCPG1 (By similarity). Interacts with CDCP1, PELP1, TGFB1I1 and TOM1L2. PTM: Phosphorylated on Tyr-530 by c-Src kinase (CSK). The phosphorylated form is termed pp60c-src. The phosphorylated tail interacts with the SH2 domain thereby repressing kinase activity. SIMILARITY: SwissProt: P12931 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. & Contains 1 protein kinase domain. & Contains 1 SH2 domain. & Contains 1 SH3 domain.
Molecular Weight
60 kDa
Product Usage Statements
Quality Assurance
routinely evaluated in (60kDa) on a RIPA lysate of chicken embryo fibroblasts (CEF)
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
