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Millipore Anti-Ox40l (Cd252) Antibody, Clone Rm134l Detects Level Of Ox40l (Cd252) & Has Been Published & Validated For Use In Flow Cytometry & Ihc. - Mill (Additional S&H or Hazmat Fees May Apply)
OX40L (Tumor necrosis factor ligand superfamily member 4; or CD252) is the endogenous ligand of the OX40 receptor. OX40 is localized on activated T-cells and propagates the immune response by promoting division and survival of T-cells, thereby increasing the population of memory CD4 and CD8 T cells produced in response to antigen detection. The OX40/OX40L may also regulate cytokine production and suppress the activity of T-regulatory cells. OX40/OX40L is therefore an important mediator of the immune response. Previous studies have suggested that OX40 signaling maybe involved in the development of autoimmune diseases.
Product Information
Format
Purified
Control
Mouse OX40L/L5178Y cells
Presentation
Purified rat monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
Anti-OX40L (CD252) Antibody, clone RM134L detects level of OX40L (CD252) & has been published & validated for use in Flow Cytometry & IHC.
Key Applications
Flow Cytometry
Immunohistochemistry
Application Notes
Immunohistochemistry Analysis: A representative lot was used by an independent laboratory in mouse lung tissue. (Hoshino, A., et al. (2003). Eur. J. Immunol. 33:861–869.)
Biological Information
Immunogen
Mouse OX40L cDNA-transfected NRK cells
Epitope
Extracellular domain
Clone
RM134L
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Rat
Specificity
This antibody recognizes the extracellular domain of OX40L.
Isotype
IgG2bκ
Species Reactivity
Mouse
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NP_033478
Gene Symbol
Tnfsf4
Ox40l
Txgp1l
Purification Method
Protein G Purified
UniProt Number
P43488
UniProt Summary
FUNCTION: Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.
SUBUNIT STRUCTURE: Homotrimer.
SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.
SEQUENCE SIMILARITIES: Belongs to the tumor necrosis factor family.
Molecular Weight
22 kDa calculated
Product Usage Statements
Quality Assurance
Evaluated by Flow Cytometry in mouse OX40L/L5178Y cells.
Flow Cytometry Analysis: 10 µg of this antibody detected OX40L in mouse OX40L/L5178Y cells.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
