| Description | |
|---|---|
| Catalogue Number | 14-723 |
| Brand Family | Upstate |
| Trade Name |
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| Description | CaM Kinase IIδ Protein, active, 10 µg |
| Overview | N-terminal 6His-tagged, recombinant, human, full length CaM Kinase IIδ N-terminal 6His-tagged, recombinant, human, full length CaM Kinase IIδ |
| Product Information | |
|---|---|
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | Active, N-terminal 6His-tagged, recombinant, human, full length CaM Kinase IIδ. For use in Kinase Assays. |
| Key Applications |
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| Biological Information | |
|---|---|
| Source | expressed by baculovirus in Sf21 cells |
| Specific Activity | For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. |
| Entrez Gene Number |
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| Entrez Gene Summary | The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Four alternatively spliced transcript variants that encode three different isoforms have been characterized to date. Distinct isoforms of this chain have different expression patterns. |
| Gene Symbol |
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| Protein Target | CaMKIIδ |
| Purification Method | Ni2+/NTA-agarose |
| Target Sub-Family | CAMK |
| UniProt Number |
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| UniProt Summary | FUNCTION: SwissProt: Q13557 # CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. SIZE: 499 amino acids; 56369 Da SUBUNIT: CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. TISSUE SPECIFICITY: Expressed in cardiac muscle and skeletal muscle. Isoform Delta 3, isoform Delta 2, isoform Delta 8 and isoform Delta 9 are expressed in cardiac muscle. Isoform Delta 11 is expressed in skeletal muscle. SIMILARITY: SwissProt: Q13557 ## Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. & Contains 1 protein kinase domain. MISCELLANEOUS: Expression of CAMK2D is significantly increased in patients suffering from dilated cardiomyopathy. |
| Molecular Weight | 58kDa |
| Product Usage Statements | |
|---|---|
| Quality Assurance | routinely evaluated by phosphorylation of 250μM ZIPtide (Catalog # 12-545) |
| Usage Statement |
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| Storage and Shipping Information | |
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| Storage Conditions | 6 months at -70°C from date of shipment |
| Packaging Information | |
|---|---|
| Material Size | 10 µg |