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Sigma-Aldrich Arachidonic Acid >95.0% Gc
List Price
$220.40
Your Price
$220.40
Sigma-Aldrich Arachidonic Acid >95.0% Gc - SIAL (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
SIAL-10931-250MG
MFG.PART:
10931-250MG
UNSPSC:
12352211
Manufacturer:
Sigma-Aldrich
biological source
fungus
Quality Level
100
assay
>95.0% (GC)
form
liquid
refractive index
n20/D 1.4872 (lit.)
bp
169-171 °C/0.15 mmHg (lit.)
mp
−49 °C (lit.)
density
0.922 g/mL at 25 °C (lit.)
functional group
carboxylic acid
lipid type
omega FAs
Related Categories
Coenzymes
Application
Arachidonic acid has been used:
- in calibration curve generation in Raman spectroscopy and atomic force microscopy (AFM) in normal and breast cancer samples[1]
- as a polyunsaturated fatty acid supplement to the reconstituted synthetic bile (RSB) in drug resistance analysis[2]
- for the activation of mechanistic target of rapamycin 1 (mTOR1) and mTOR2[3]
Biochem/physiol Actions
Arachidonic acid (AA) is an unsaturated ω6 fatty acid constituent of the phospholipids of cell membranes. Phospholipase A2 releases AA from the membrane phospholipids in response to inflammation. AA is subsequently metabolized to prostaglandins and thromboxanes by at least two cyclooxygenase (COX) isoforms, to leukotrienes and lipoxins by lipoxygenases, and to epoxyeicosatrienoic acids via cytochrome p450-catalyzed metabolism. AA and its metabolites play important roles in a variety of biological processes, including signal transduction, smooth muscle contraction, chemotaxis, cell proliferation and differentiation, and apoptosis. AA has been demonstrated to bind to the a subunit of G protein and inhibit the activity of Ras GTPase-activating proteins (GAPs). Cellular uptake of AA is energy dependent and involves protein-facilitated transport across the plasma membrane.
Arachidonic acid stimulates adhesion of MDA-MB-435 human metastatic cancer cells to extracellular matrix molecules (collagen IV and vitronectin) .
pictograms
GHS07
signalword
Warning
hcodes
H315,H319
pcodes
P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
wgk_germany
WGK 3
ppe
Eyeshields, Faceshields, Gloves, multi-purpose combination respirator cartridge (US)
| SKU | SIAL-10931-250MG |
|---|---|
| Featured | No |
| Supplier Part Number | 10931-250MG |
| UM | EA |
| UNSPSC | 12352211 |
| Manufacturer Name | Sigma-Aldrich |
| Temperature | -20C |
| Refrigerated-Frozen | Y |
| ProductLine | SIAL |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 10.000000 |
| Lead Time | 9 |
| Hazardous | Y |
| CAS Number | 506-32-1 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |
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