Sigma-Aldrich Arachidonic Acid >95.0% Gc

List Price $220.40 Your Price $220.40
Sigma-Aldrich Arachidonic Acid >95.0% Gc - SIAL (Additional S&H Or Hazmat Fees May Apply)
NETA PART: SIAL-10931-250MG
MFG.PART: 10931-250MG
UNSPSC: 12352211
Manufacturer: Sigma-Aldrich

biological source

fungus

Quality Level

100

assay

>95.0% (GC)

form

liquid

refractive index

n20/D 1.4872 (lit.)

bp

169-171 °C/0.15 mmHg (lit.)

mp

−49 °C (lit.)

density

0.922 g/mL at 25 °C (lit.)

functional group

carboxylic acid

lipid type

omega FAs

Related Categories

Coenzymes

Application

Arachidonic acid has been used:
  • in calibration curve generation in Raman spectroscopy and atomic force microscopy (AFM) in normal and breast cancer samples[1]
  • as a polyunsaturated fatty acid supplement to the reconstituted synthetic bile (RSB) in drug resistance analysis[2]
  • for the activation of mechanistic target of rapamycin 1 (mTOR1) and mTOR2[3]

Biochem/physiol Actions

Arachidonic acid (AA) is an unsaturated ω6 fatty acid constituent of the phospholipids of cell membranes. Phospholipase A2 releases AA from the membrane phospholipids in response to inflammation. AA is subsequently metabolized to prostaglandins and thromboxanes by at least two cyclooxygenase (COX) isoforms, to leukotrienes and lipoxins by lipoxygenases, and to epoxyeicosatrienoic acids via cytochrome p450-catalyzed metabolism. AA and its metabolites play important roles in a variety of biological processes, including signal transduction, smooth muscle contraction, chemotaxis, cell proliferation and differentiation, and apoptosis. AA has been demonstrated to bind to the a subunit of G protein and inhibit the activity of Ras GTPase-activating proteins (GAPs). Cellular uptake of AA is energy dependent and involves protein-facilitated transport across the plasma membrane.
Arachidonic acid stimulates adhesion of MDA-MB-435 human metastatic cancer cells to extracellular matrix molecules (collagen IV and vitronectin) .

pictograms

GHS07

signalword

Warning

hcodes

H315,H319

pcodes

P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

wgk_germany

WGK 3

ppe

Eyeshields, Faceshields, Gloves, multi-purpose combination respirator cartridge (US)

More Information
SKU SIAL-10931-250MG
Featured No
Supplier Part Number 10931-250MG
UM EA
UNSPSC 12352211
Manufacturer Name Sigma-Aldrich
Temperature -20C
Refrigerated-Frozen Y
ProductLine SIAL
Qty 1
MinOrderQty 1
Weight 10.000000
Lead Time 9
Hazardous Y
CAS Number 506-32-1
Energy Star No
Green No
ACT Ecolabel No
Controlled N
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