Sigma-Aldrich (+)-Tubocurarine Chloride

Assay

≥98% (HPLC)

Quality Level

100

Form

solid

Manufacturer/Tradename

Calbiochem^®

Storage Condition

OK to freeze
protect from light

Color

white

Solubility

H₂O: soluble

Storage Temp.

−20°C

Inchi

1S/C37H40N2O6.2ClH/c1-38-14-12-24-19-32(42-4)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-37-35-25(20-34(43-5)36(37)41)13-15-39(2,3)29(35)17-23-8-11-30(40)31(18-23)45-33;;/h6-11,18-21,28-29H,12-17H2,1-5H3,(H-,40,41);2*1H/t28-,29+;;/m0../s1

Inchi Key

GXFZCDMWGMFGFL-KKXMJGKMSA-N

General Description

A potent competitive antagonist of nAChR (IC50= 41 nM). Used as nondepolarizing muscle relaxants during electroshock treatments, in convulsive states, and as anesthesia adjuvant.A potent competitive antagonist of nAChR (IC₅₀= 41 nM). Used as nondepolarizing muscle relaxants during electroshock treatments, in convulsive states, and as anesthesia adjuvant.

Biochem/Physiol Actions

Primary Target
nAch

Warning

Toxicity: Toxic (F)

Preparation Note

Warming is required for complete solubilization.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Bowman, C., 2006.Br. J. Pharmacol. 147,S277.
Wenningmann, I., et al. 2001.Mol. Pharmacol. 60,790.
Pederson, X., 1990.Proc. Natl. Acad. Sci. USA. 87,2785.Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, GermanyGHS06H300P264 - P270 - P301 + P310 - P405 - P501