Cell Signaling Pank1 (D2w3n) Rabbit mAb

Name: Cell Signaling Pank1 (D2w3n) Rabbit mAb
SKU: CSIG-23887S
Price: 342.39 USD

List Price $342.39 Your Price $342.39

Cell Signaling Pank1 (D2w3n) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-23887S

MFG.PART: 23887S

UNSPSC: 12352300

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	H Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	50
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:50}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	PANK1 (D2W3N) Rabbit mAb recognizes endogenous levels of total PANK1 protein.
Species Reactivity	Human, Monkey
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro153 of human PANK1 protein.
Background	Pantothenate kinase 1 (PANK1) is the rate-limiting enzyme in coenzyme A (CoA) synthesis (1,2). PPARα -mediated transcriptional regulation of PANK1 plays an important role in controlling CoA levels in hepatocytes (1). Research studies indicate that PANK1 expression, along with microRNA-107, decreases in a murine macrophage model upon lipopolysaccharide (LPS) exposure in a PPARα-dependent manner (3). Additional studies show that the corresponding PANK1 gene is a direct target of tumor suppressor p53 and that p53 regulates energy homeostasis through control of PANK1 expression (2).

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