Cell Signaling Pla2g1b (D1t4c) Rabbit mAb

Name: Cell Signaling Pla2g1b (D1t4c) Rabbit mAb
SKU: CSIG-14635S
Price: 342.39 USD

List Price $342.39 Your Price $342.39

Cell Signaling Pla2g1b (D1t4c) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-14635S

MFG.PART: 14635S

UNSPSC: 12352300

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	M R
Sensitivity	Endogenous
Molecular Weight (kDa)	16
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	PLA2G1B (D1T4C) Rabbit mAb recognizes endogenous levels of total PLA2G1B protein.
Species Reactivity	Mouse, Rat
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu80 of human PLA2G1B protein.
Background	Phospholipase A2 (PLA2) is a superfamily of enzymes that hydrolyze glycero-3-phosphocholines and release fatty acids and lysophospholipids (1). PLA2G1B is a member of this superfamily in the 1B group that is expressed most highly in the pancreatic acinar cells (2). Evidence suggests that PLA2G1B plays a role in the absorption and storage of extra energy as fats are metabolized (1,2). Lysophospholipids generated by PLA2G1B inhibit fatty acid oxidation in the liver and reduce energy expenditure, leading to diet-induced obesity and type 2 diabetes with a high fat diet (1). Therefore, a potential intervention of obesity and diabetes could target PLA2G1B in the digestive tract (2).

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