Cell Signaling Phospho-Pfkfb2 (Ser483) (D4r1w) Rabbit mAb

Name: Cell Signaling Phospho-Pfkfb2 (Ser483) (D4r1w) Rabbit mAb
SKU: CSIG-13064S
Price: 405.01 USD

List Price $405.01 Your Price $405.01

Cell Signaling Phospho-Pfkfb2 (Ser483) (D4r1w) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-13064S

MFG.PART: 13064S

UNSPSC: 12352300

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	55
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	Phospho-PFKFB2 (Ser483) (D4R1W) Rabbit mAb recognizes endogenous levels of PFKFB2 protein only when phosphorylated at Ser483.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser483 of human PFKFB2 protein.
Background	The bifunctional 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFK/FBPase or PFKFB) catalyzes the synthesis and degradation of fructose 2,6-bisphosphate and regulates its steady-state level (1,2). Fructose 2,6-bisphosphate activates phosphofructokinase, a rate-limiting enzyme in glycolysis, by allosteric regulation (1,2). Four different PFKFB isoforms (PFKFB1, PFKFB2, PFKFB3, and PFKFB4) have been identified (1,2). Research studies indicate that amino acids activate PFKFB2 through Akt-dependent phosphorylation at Ser483 on PFKFB2 (3). In addition, androgen increases the expression of PFKFB2 in prostate cancer cells (4).

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